Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
![GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0463-3/MediaObjects/13046_2016_463_Fig3_HTML.gif)
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text
![RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism - ScienceDirect RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0304383518306682-gr5.jpg)
RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism - ScienceDirect
![Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/3b86e0f9-0fe1-422e-90e4-140f6e14606d/mfig006.jpg)
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library
![Cells | Free Full-Text | Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer | HTML Cells | Free Full-Text | Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer | HTML](https://www.mdpi.com/cells/cells-08-00394/article_deploy/html/images/cells-08-00394-g001.png)
Cells | Free Full-Text | Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer | HTML
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
![Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/dfcbe7e6-001f-48e4-8320-845455d994b7/mfig003.jpg)
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo - Wickström - 2013 - International Journal of Cancer - Wiley Online Library
![GANT-61 treatment to RMS cells inhibits proliferation, colony formation... | Download Scientific Diagram GANT-61 treatment to RMS cells inhibits proliferation, colony formation... | Download Scientific Diagram](https://www.researchgate.net/profile/Changzhao_Li/publication/269038807/figure/fig3/AS:295413031686145@1447443363323/GANT-61-treatment-to-RMS-cells-inhibits-proliferation-colony-formation-and-induces-cell.png)
GANT-61 treatment to RMS cells inhibits proliferation, colony formation... | Download Scientific Diagram
![Frontiers | The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation | Oncology Frontiers | The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation | Oncology](https://www.frontiersin.org/files/Articles/435530/fonc-09-00391-HTML/image_m/fonc-09-00391-g003.jpg)
Frontiers | The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation | Oncology
![Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe | Cell Death & Disease Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41419-017-0142-0/MediaObjects/41419_2017_142_Fig1_HTML.jpg)
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe | Cell Death & Disease
![GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0463-3/MediaObjects/13046_2016_463_Fig7_HTML.gif)
GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text
![Schematic overview of different GANT61 target sites. Inhibition of the... | Download Scientific Diagram Schematic overview of different GANT61 target sites. Inhibition of the... | Download Scientific Diagram](https://www.researchgate.net/profile/Annelies_Gonnissen/publication/277958538/figure/fig2/AS:294420114100265@1447206633948/Schematic-overview-of-different-GANT61-target-sites-Inhibition-of-the-GLI-transcription.png)
Schematic overview of different GANT61 target sites. Inhibition of the... | Download Scientific Diagram
![GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0463-3/MediaObjects/13046_2016_463_Fig2_HTML.gif)